Nasopharyngeal (nay-zoh-fuh-RIN-jee-ul) carcinoma is cancer that occurs in the nasopharynx, which is located behind your nose and above the back of your throat.
Nasopharyngeal carcinoma is rare in the United States. It occurs much more frequently in other parts of the world — specifically Southeast Asia.
Nasopharyngeal carcinoma is difficult to detect early. That's probably because the nasopharynx isn't easy to examine and symptoms of nasopharyngeal carcinoma mimic those of other, more-common conditions.
Treatment for nasopharyngeal carcinoma usually involves radiation therapy, chemotherapy or a combination of the two. You can work with your doctor to determine the exact approach depending on your particular situation.
In its early stages, nasopharyngeal carcinoma may not cause any symptoms. Possible noticeable symptoms of nasopharyngeal carcinoma include:
Early nasopharyngeal carcinoma symptoms may not always prompt you to see your doctor. However, if you notice any unusual and persistent changes in your body that don't seem right to you, such as unusual nasal congestion, see your doctor.
Cancer begins when one or more genetic mutations cause normal cells to grow out of control, invade surrounding structures and eventually spread (metastasize) to other parts of the body. In nasopharyngeal carcinomas, this process begins in the squamous cells that line the surface of the nasopharynx.
Exactly what causes the gene mutations that lead to nasopharyngeal carcinoma isn't known, though factors, such as the Epstein-Barr virus, that increase the risk of this cancer have been identified. However, it isn't clear why some people with all the risk factors never develop cancer, while others who have no apparent risk factors do.
Researchers have identified some factors that appear to increase your risk of developing nasopharyngeal carcinoma, including:
Nasopharyngeal carcinoma complications can include:
Cancer that spreads to other areas of the body. Nasopharyngeal carcinoma frequently spreads (metastasizes) beyond the nasopharynx.
Most people with nasopharyngeal carcinoma have regional metastases. That means cancer cells from the initial tumor have migrated to nearby areas, such as lymph nodes in the neck.
Cancer cells that spread to other areas of the body (distant metastases) most commonly travel to the bones, lungs and liver.
No sure way exists to prevent nasopharyngeal carcinoma. However, if you're concerned about your risk of nasopharyngeal carcinoma, you may consider avoiding habits that have been associated with the disease. For instance, you may choose to cut back on the amount of salt-cured foods you eat or avoid these foods altogether.
In the United States and in other areas where the disease is rare, routine screening for nasopharyngeal carcinoma isn't done.
But in areas of the world where nasopharyngeal carcinoma is much more common — for instance, in some areas of China — doctors may offer screenings to people thought to be at high risk of the disease. Screening may involve blood tests to detect the Epstein-Barr virus.
Tests and procedures used to diagnose nasopharyngeal carcinoma include:
Exam using a camera to see inside your nasopharynx. If nasopharyngeal carcinoma is suspected, your doctor may recommend a nasal endoscopy.
This test uses a thin, flexible tube with a camera on the end to see inside your nasopharynx and look for abnormalities. The camera may be inserted through your nose or through the opening in the back of your throat that leads up into your nasopharynx.
Nasal endoscopy may require local anesthesia.
Once the diagnosis is confirmed, your doctor orders other tests to determine the extent (stage) of the cancer, such as imaging tests.
Imaging tests may include:
Once your doctor has determined the extent of your cancer, a Roman numeral that signifies its stage is assigned. The stages of nasopharyngeal cancer range from I to IV.
The stage is used along with several other factors to determine your treatment plan and your prognosis. A lower numeral means the cancer is small and confined to the nasopharynx. A higher numeral means cancer has spread beyond the nasopharynx to lymph nodes in the neck or to other areas of the body.
You and your doctor work together to devise a treatment plan based on several factors, such as the stage of your cancer, your treatment goals, your overall health and the side effects you're willing to tolerate.
Treatment for nasopharyngeal carcinoma usually begins with radiation therapy or a combination of radiation and chemotherapy.
Radiation therapy uses high-powered energy beams, such as X-rays or protons, to kill cancer cells.
Radiation therapy for nasopharyngeal carcinoma is usually administered in a procedure called external beam radiation. During this procedure, you're positioned on a table and a large machine is maneuvered around you, directing radiation to the precise spot where it can target your cancer.
For small nasopharyngeal tumors, radiation therapy may be the only treatment necessary. In other situations, radiation therapy may be combined with chemotherapy.
Radiation therapy carries a risk of side effects, including temporary skin redness, hearing loss and dry mouth.
A type of internal radiation therapy, called (brachytherapy), is sometimes used in recurrent nasopharyngeal carcinoma. With this treatment, radioactive seeds or wires are positioned in the tumor or very close to it.
Radiation therapy to the head and neck, especially when combined with chemotherapy, often causes severe sores in the throat and mouth. Sometimes these sores make it difficult to eat or drink. If this occurs, your doctor may recommend inserting a tube into your throat or stomach. Food and water are delivered through the tube until your mouth and throat recover.
Chemotherapy is a drug treatment that uses chemicals to kill cancer cells. Chemotherapy drugs can be given in pill form, administered through a vein or both. Chemotherapy may be used to treat nasopharyngeal carcinoma in three ways:
Chemotherapy at the same time as radiation therapy. When the two treatments are combined, chemotherapy enhances the effectiveness of radiation therapy. This combined treatment is called concomitant therapy or chemoradiation.
However, side effects of chemotherapy are added to the side effects of radiation therapy, making concomitant therapy more difficult to tolerate.
Chemotherapy after radiation therapy. Your doctor might recommend chemotherapy after radiation therapy or after concomitant therapy.
Chemotherapy is used to attack any remaining cancer cells in your body, including those that may have broken off from the original tumor and spread elsewhere.
Some controversy exists as to whether additional chemotherapy actually improves survival in people with nasopharyngeal carcinoma. Many people who undergo chemotherapy after concomitant therapy are unable to tolerate the side effects and must discontinue treatment.
What chemotherapy drugs you receive and how often will be determined by your doctor. The side effects you're likely to experience will depend on which drugs you receive.
Surgery is not often used as a treatment for nasopharyngeal carcinoma. Surgery may be used to remove cancerous lymph nodes in the neck.
In certain cases, surgery may be used to remove a tumor from the nasopharynx. This usually requires surgeons to make an incision in the roof of your mouth to access the area to remove the cancerous tissue.
Radiation therapy for nasopharyngeal carcinoma often causes dry mouth (xerostomia).
Having a dry mouth can be uncomfortable. It can also lead to frequent infections in your mouth and difficulty eating, swallowing and speaking, and can increase problems with the health of your teeth. Ask your doctor whether you should see a dentist if you experience dry mouth complications.
You may find some relief from dry mouth and its complications if you:
Tell your doctor if you have dry mouth. He or she may provide treatments to help you cope with more-severe signs and symptoms of dry mouth. Your doctor may also refer you to a dietitian who can help you find foods that are easier to eat if you're experiencing dry mouth.
Everyone deals with a cancer diagnosis in his or her own way. You might experience shock and fear after your diagnosis. Allow yourself time to grieve.
A cancer diagnosis can make you feel as if you have little control, so take steps to empower yourself and control what you can about your health. Try to:
Learn enough to feel confident making decisions. Write down questions and ask them at the next appointment with your doctor. Get a friend or family member to come to appointments with you to take notes.
Ask your health care team for further sources of information. Gather enough information so that you feel confident in making decisions about your treatment.
Find someone to talk to. You may find it helps to have someone to talk to about your emotions. This may be a close friend or family member who is a good listener.
Other people who may provide support include social workers and psychologists — ask your doctor for a referral. Talk with your pastor, rabbi, imam or other spiritual leader.
Other people with cancer can offer a unique perspective, so consider joining a support group — whether it's in your community or online. Contact the American Cancer Society for more information on support groups.
Take care of yourself. Prepare yourself for treatment by making healthy lifestyle choices. For instance, if you smoke, quit smoking.
Eat a variety of fruits and vegetables. Get exercise when you feel up to it, but check with your doctor before starting a new exercise program.
Try to get enough sleep so that you wake feeling refreshed. Talk to your doctor if you're having trouble sleeping. Try to control stress by prioritizing what's important to you.
These healthy choices can make it easier for your body to cope with the side effects of treatment.
If your doctor suspects or has diagnosed nasopharyngeal cancer, you may be referred to a doctor who specializes in treating cancer (oncologist) or to a doctor who specializes in ear, nose and throat problems (otolaryngologist).
Because appointments can be brief, and it can be difficult to remember everything you want to discuss, it's a good idea to be well-prepared. Here are some suggestions for getting ready, and what to expect from your doctor.
List your most important questions first, in case time runs out. For nasopharyngeal carcinoma, some basic questions to ask include:
And if your doctor says something that's not clear, don't hesitate to ask.
Your doctor will likely have a number of questions for you. If you're ready to answer them, it may save time for more of your questions. Some potential questions your doctor might ask include:
© 1998-2021 Mayo Foundation for Medical Education and Research (MFMER). All rights reserved.