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Home Health Library Frequently Asked Questions Mononucleosis and Epstein-Barr: What's the connection?

Mononucleosis and Epstein-Barr: What's the connection?

The Epstein-Barr virus sometimes causes a disease known as mono. Learn who is at risk and what the symptoms are.

Answer Section

Epstein-Barr virus (EBV) can cause the disease mononucleosis, also known as mono. EBV is one of the most common viruses that people catch. But it takes more than a cough or sneeze to spread EBV. The virus spreads from person to person mainly through saliva.

EBV doesn't cause symptoms in most people. You can catch it from an infected person by doing things such as:

  • Kissing.
  • Sharing food and drinks.
  • Sharing cups, utensils or toothbrushes.

Mono can cause symptoms such as:

  • Extreme tiredness.
  • Fever.
  • Sore throat.
  • Headaches and body aches.
  • Swollen lymph nodes.
  • Swelling in the liver, spleen or both.
  • Rash.

There's no clear-cut treatment for mono. You can take steps to ease the symptoms by:

  • Drinking water or other fluids to stay hydrated.
  • Getting lots of rest.
  • Taking medicine that you can get without a prescription for pain and fever.

Some people need treatment for other health problems caused by mono. But most people with mono feel better in a couple weeks, although tiredness can last for longer, up to several months.

Last Updated: December 30th, 2025